Dev125211 2554..2563
نویسندگان
چکیده
The adult mammalian ovary is devoid of definitive germline stem cells. As such, female reproductive senescence largely results from the depletion of a finite ovarian follicle pool that is produced during embryonic development. Remarkably, the crucial nature and regulation of follicle assembly and survival during embryogenesis is just coming into focus. This developmental pathway involves the coordination of meiotic progression and the breakdown of germ cell cysts into individual oocytes housedwithin primordial follicles. Recent evidence also indicates that genetic and environmental factors can specifically perturb primordial follicle assembly. Here, we review the cellular and molecular mechanisms by which the mammalian ovarian reserve is established, highlighting the presence of a crucial checkpoint that allows survival of only the highest-quality oocytes.
منابع مشابه
ATCA ⋆ H i Observations of the Peculiar Galaxy IC 2554
ATCA H i and radio continuum observations of the peculiar southern galaxy IC 2554 and its surroundings reveal typical signatures of an interacting galaxy group. We detected a large H i cloud between IC 2554 and the elliptical galaxy NGC 3136B. The gas dynamics in IC 2554 itself, which is sometimes described as a colliding pair, are surprisingly regular, whereas NGC 3136B was not detected. The H...
متن کاملPartly Based on Observations with the Eso 2.2 M Telescope at La Silla/chile (mpi Time)
1 The discovery of the supersoft X-ray source RX J0527.8–6954 during the ROSAT first light observation (Trümper et al. 1991) of the Large Magellanic Cloud (LMC) in June 1990 has directed some attention to the optical variable HV 2554 because its location is within the X-ray error circle of RX J0527.8–6954 (Trümper et al. 1991, Greiner et al. 1991). Later ROSAT observations improved the X-ray po...
متن کاملFibroblast Growth Factor Receptor 3 Epidermal Naevus Syndrome with Urothelial Mosaicism for the Activating p.Ser249Cys FGFR3 Mutation.
متن کامل
Some properties for integro-differential operator defined by a fractional formal
Recently, the study of the fractional formal (operators, polynomials and classes of special functions) has been increased. This study not only in mathematics but extended to another topics. In this effort, we investigate a generalized integro-differential operator [Formula: see text] defined by a fractional formal (fractional differential operator) and study some its geometric properties by emp...
متن کاملOn planarity of compact, locally connected, metric spaces
Thomassen [Combinatorica 24 (2004), 699–718] proved that a 2–connected, compact, locally connected metric space is homeomorphic to a subset of the sphere if and only if it does not contain K5 or K3,3. The “thumbtack space” consisting of a disc plus an arc attaching just at the centre of the disc shows the assumption of 2–connectedness cannot be dropped. In this work, we introduce “generalized t...
متن کامل